I already use a Wii remote to help me with my Animation Mentor critiques, photoshop, and TVPaint, but I essentially just use it as a wireless keyboard replacement. I had no idea it could be used for so much more. Johnny Lee has turned the Wii remote into an interactive white board and a 3D Game display. If your interested in this kid of stuff, check out his talk on TED:
TED has turned into a kick ass place for people to present ideas. I really like the videos they publish.